Molecular Phylogeny and Evolution

After completion of the course student will be able to:

1. CO1Understand phylogenetic trees, their types, topological differences, and tree-building methods (UPGMA, LS, NJ, reconstruction).K2
2. CO2Apply maximum parsimony and maximum likelihood methods for consensus trees, branch length estimation, and protein data analysis.K3
3. CO3Explain statistical approaches in phylogenetics, including optimization principles, bootstrap tests, molecular clocks, and linearized trees.K2
4. CO4Apply parsimony and Bayesian approaches to infer ancestral sequences and explain synonymous/non-synonymous substitutions, convergent and parallel evolution.K3
5. CO5Explain the molecular basis of evolution, genetic polymorphism, and population trees derived from genetic markers.K2

1. / REFERENCES
2. Bruce S. Lieberman, “Phylogenetics: Theory and Practice of Phylogenetic Systematics”, Wiley-Blackwell, second edition, 2011.
3. Masatoshi Nei, “Molecular Evolution and Phylogenetics”, Oxford University Press, 2000.
4. David W Mount, “Bioinformatics- Sequence and genome analysis”, Cold Spring Harbor Laboratory Press, second edition, 2004.
5. Roderick D.M. Page, Dr Edward C. Holmes, “Molecular Evolution: A Phylogenetic Approach”, Blackwell Publishing, 1998.
6. Jin Xiong, “Essential Bioinformatics”, Cambridge University Press, 2006. Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh