BBI058

Cancer Biology

L-T-P3-0-0 Credits3 Session2026-27 TypeTheory
Appears in 1 semester

B.Tech Bioinformatics · Sem 5 (Departmental Elective-II)

Syllabus

5 units · 40 lecture hours
Unit1

Unit 1: FUNDAMENTALS OF CANCER BIOLOGY

8 hrs

Regulation of Cell cycle- Mutations that cause changes in signal molecules- effects on receptor- signal switches tumour suppressor genes- Modulation of cell cycle-in cancer- Different forms of cancers- Diet and cancer.

Unit2

Unit 2: PRINCIPLES OF CARCINOGENESIS

8 hrs

Chemical Carcinogenesis Metabolism of Carcinogenesis- Natural History of Carcinogenesis- Targets of Chemical Carcinogenesis- Principles of Physical Carcinogenesis- X-Ray radiation - Mechanism of radiation Carcinogenesis.

Unit3

Unit 3: PRINCIPLES OF MOLECULAR CELL BIOLOGY OF CANCER

8 hrs

Oncogenes- Identification of Oncogenes- Retroviruses and Oncogenes- detection of Oncogenes- Growth factor and Growth factor receptors that are Oncogenes- Oncogenes/ Proto Oncogenes activity- Growth factors related to transformations.

Unit4

Unit 4: PRINCIPLES OF CANCER METASTASIS

8 hrs

Clinical significances of invasion- heterogeneity of metastatic phenotype- Metastatic cascade- Basement membrane disruption- Three step theory of invasion- Proteinases and tumour cell invasion.

Unit5

Unit 5: NEW MOLECULES FOR CANCER THERAPY

8 hrs

Different forms of therapy- Chemotherapy- Radiation Therapy- Detection of Cancers- Prediction of aggressiveness of Cancer- Advances in Cancer detection- Bioinformatics and Cancer. Role of machine Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh learning and deep learning in cancer research. Cancer screening and detection via AI integration.

Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Understand fundamentals of cancer biology including cell cycle regulation, mutations, tumour suppressor genes, and cancer types.K2
  2. CO2Apply principles of carcinogenesis (chemical, physical, radiation mechanisms).K3
  3. CO3Explain molecular cell biology of cancer focusing on oncogenes, growth factors, and transformations.K2
  4. CO4Explain principles of cancer metastasis including invasion, heterogeneity, and the metastatic cascade.K2
  5. CO5Describe new molecules and therapies for cancer, including chemotherapy, radiation, bioinformatics, and advances in detection and AI integration.K2

TEXT BOOKS

  1. / REFERENCES
  2. King R. J. B., “Cancer Biology”, Addison Wesley Longmann Ltd, U.K., 1996.
  3. Ruddon R.W., “Cancer Biology”, Oxford University Press, Oxford, 1995.
  4. Maly B.W.J., “Virology a practical approach”, IRL press, Oxford, 1987.
  5. Dunmock N.J. and Primrose S.B., “Introduction to modern Virology”, Well Scientific Publications, Oxford, 1988. Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh

Official AKTU syllabus

This subject is on page 24, 25, 26 of the original AKTU PDF.

Official AKTU syllabus PDF ↗