Unit1
Unit 1: STRUCTURE OF NUCLEIC ACID
8 hrsStructure of DNA - Different forms of DNA and RNA Identification of DNA as genetic material by Griffith–Avery, McLeod and McCarty-Frankel and Singer- Hershey and ChaseMesselson and Stahl experiment.
Syllabus
5 units · 40 lecture hoursUnit2
Unit 2: DNA REPLICATION AND MUTATION
8 hrsSemi-Conservative replication - replication of DNA in Eukaryotes - molecular basis of Mutation- classification of mutation, DNA Repair mechanism
Unit3
Unit 3: GENE EXPRESSION AND REGULATION
8 hrsGenetic code – transcription- prokaryotes and Eukaryotes- Post transcriptional modification - Translation in prokaryotes and Eukaryotes - Post translational modification-Gene Regulation- Lac operon model
Unit4
Unit 4
8 hrsMENDELIAN GENETICS – monohybrid – dihybrid inheritance- multiple alleles- structure and organization of chromosome in prokaryote and Eukaryotes.
Unit5
Unit 5: CROSSING OVER AND LINKAGE
8 hrsLinkage –types of linkage-crossing over and their types Recombination mapping by two point and three point text cross mapping in bacteria.
Course Outcomes (COs)
After completion of the course student will be able to:
- CO1Understand the fundamental Structure of DNAK2
- CO2Discuss the process of DNA replication & different repair mechanisms.K2
- CO3Discuss the process of Gene expression and its regulation, DNA repair and Comprehend mutation and its causesK3
- CO4Understand the basis of inheritance and chromosome organizationK2
- CO5Discuss linkage and crossing over mechanism of chromosomeK3
Text books
- Genetics a conceptual approach, 2nd Edition Benjamin A. Pierc WH freeman and, company, New York
- Advance Genetics by G.S. Miglani, Narosa Publishing House.
- Albert B, Bray Denis et al.: Molecular Biology of The Cell, latest ed.
- Watson, Hopkins, Roberts et al. Molecular Biology of the Gene, 4 th ed.
- Genetics-Strickberger, 2nd.
- Baltimore-Molecular Biology of the Cell
Official AKTU syllabus
This subject is on page 10 of the original AKTU PDF.