UNIQUE SERIES AKTU Syllabus
BP204T

Pharmaceutical Organic Chemistry (Theory)

L-T-P4-0-0 Credits4 Session2026-27 TypeTheory
Appears in 1 semester

B.Pharm · Sem 2 (Core)

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Syllabus

5 units · 60 lecture hours
Unit1

Unit 1

12 hrs

Aliphatic Saturated Hydrocarbons Alkanes Clemmensen reduction, Wolff Kishner reduction Chemical reactions of alkanes Mechanism of free radical substitution (halogenation) Pharmaceutical applications of alkanes: Liquid paraffin, soft paraffin, hard paraffin Cycloalkanes Coulson Moffitt modification Sachse Mohr theory

Unit2

Unit 2

12 hrs

Aliphatic Unsaturated Hydrocarbons - Alkenes Methods of preparation: o Dehydration of alcohols o Dehydrohalogenation of alkyl halides o Dehalogenation of vicinal dihalides o Wittig reaction Chemical reactions of alkenes Mechanism of electrophilic addition reactions - Ozonolysis Conjugated Dienes Stability of conjugated dienes Mechanism of Diels Alder reaction Electrophilic and free radical addition reactions 1,2- and 1,4-addition reactions

Unit3

Unit 3

12 hrs

Alkyl Halides Nucleophilic substitution reactions: SN1 and SN2 o Mechanism, kinetics, substrate structure, solvent effect, stereochemistry Elimination reactions: E1 and E2 o Mechanism, kinetics, substrate structure, solvent effect, stereochemistry Comparison of substitution vs elimination reactions

Unit4

Unit 4

12 hrs

: Benzene and Its Derivatives - IUPAC nomenclature of mono- and di-substituted benzene derivatives Structure of benzene Molecular orbital picture and resonance Electrophilic aromatic substitution reactions: o Nitration o Halogenation o Friedel Crafts alkylation and its limitations o Friedel Crafts acylation o Sulphonation and desulphonation Effect of substituents on reactivity and orientation

Unit5

Unit 5

12 hrs

Carbonyl Compounds - Aldehydes and Ketones Preparation and properties of carbonyl compounds Nucleophilic addition reactions Aldol condensation and crossed aldol condensation Cannizzaro and crossed Cannizzaro reactions Benzoin and Perkin condensation Oxidation and reduction reactions Pharmaceutical applications of carbonyl compounds: Chloral, Paraldehyde, Ketoprofen

Course Objectives6 points
  • The objectives of this course are to:
  • Develop a clear understanding of the chemistry of saturated hydrocarbons.
  • Study the chemistry and reactions of unsaturated hydrocarbons.
  • Understand the chemistry and reaction mechanisms of alkyl halides.
  • Explain the chemistry of aromatic hydrocarbons and their derivatives.
  • Provide an understanding of carbonyl compounds and fundamental organic reaction mechanisms relevant to pharmaceuticals.
Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Describe the chemical reactions and mechanisms of aliphatic saturated hydrocarbons.
  2. CO2Explain the reactions and mechanisms of aliphatic unsaturated hydrocarbons.
  3. CO3Understand nucleophilic substitution and elimination reactions of alkyl halides.
  4. CO4Explain electrophilic aromatic substitution reactions and the effect of substituents.
  5. CO5Apply knowledge of carbonyl compounds and reaction mechanisms in pharmaceutical chemistry.
Recommended References (Preferably latest editions):4 books
  1. Morrison, R.T., Boyd, R.N. and Bhattacharjee, S.K., Organic Chemistry. Pearson Education India.
  2. Finar, I.L., Organic Chemistry, Vol. I. Pearson Books.
  3. Bahl, B.S. and Bahl, A., Textbook of Organic Chemistry. S. Chand & Company.
  4. Furniss, B.S., . Course Title Course Type

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Official AKTU syllabus

This subject is on page 44, 45, 46, 47 of the original AKTU PDF.

Official AKTU syllabus PDF ↗