UNIQUE SERIES AKTU Syllabus
BP211P

Physical Pharmaceutics (Practical)

L-T-P0-0-3 Credits1 Session2026-27 TypeLab / Practical
Appears in 1 semester

B.Pharm · Sem 2 (Lab)

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List of Experiments / Activities

  1. Physical Pharmaceutics (Practical) Core Credit Hours Per Week (L-T-P) Max. Hours L T P
  2. 1-- --
  3. 45Maximum Marks SE ESE
  4. (Minimum 12 experiments must be performed)
  5. 1Determination of surface tension of given liquids by drop count method and drop weight method.
  6. 2Determination of critical micellar concentration (CMC) of surfactants.
  7. 3viscometer.
  8. 4Determination of HLB value of a surfactant.
  9. 5Calculation of isotonicity by different methods (Sodium Chloride Equivalent Method).
  10. 6Determination of particle size and particle size distribution using sieving method.
  11. 7Determination of particle size and particle size distribution using microscopic method.
  12. 8Determination of densities and derived properties of powders (bulk density, tapped
  13. 9Determination of angle of repose and influence of glidants on angle of repose.
  14. 10Determination of solubility of a drug at different pH/buffer systems at room temperature.
  15. 11Determination of partition coefficient of a drug in n-octanol and water system.
  16. 12Determination of partition coefficient of a drug in benzene and water system.
  17. 13Determination of critical solution temperature and composition of phenol water system.
  18. 14Determination of specific surface area of charcoal by adsorption of acetic acid on activated charcoal.
  19. 15Determination of buffer capacity at various stages of titration of a weak acid against a strong base and determination of pKa.
  20. Note: Compare the values of various physicochemical properties with marketed formulations wherever possible.
Course Objectives6 points
  • The objectives of this course are to:
  • Introduce basic laboratory techniques for determining physicochemical properties such as surface tension, viscosity, and density in pharmaceutical systems.
  • Develop understanding of interfacial phenomena and surfactant behavior, including micelles, critical micellar concentration (CMC), and HLB in formulation design.
  • Train students in evaluating disperse systems through sedimentation studies and the effect of suspending agents.
  • Provide practical experience in powder characterization, including particle size distribution, density, flow properties, porosity, and the role of glidants.
  • Develop skills in determining solubility, partition coefficient, buffer capacity, and related equilibria relevant to drug formulation.
Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Demonstrate practical knowledge of principles and procedures involved in measuring surface tension, viscosity, density, and related physical properties using standard laboratory apparatus.
  2. CO2Determine and interpret surfactant-related parameters such as CMC and HLB and explain their significance in formulation stability and performance.
  3. CO3Conduct experiments and analyze results related to sedimentation volume and evaluate the influence of type and concentration of suspending agents on dispersion stability.
  4. CO4Evaluate micromeritic and flow properties of powders by determining particle size repose, true density, and porosity, and interpret the effect of glidants.
  5. CO5Perform and assess experiments on solubility, partition coefficient, critical solution temperature, adsorption studies, and buffer capacity, and apply findings to formulation decisions.
Recommended References (Preferably latest editions)5 books
  1. Sinko, P. J. Lippincott Williams & Wilkins.
  2. Aulton, M. E. and Taylor, K. M. G. Manufacture of Medicines. Elsevier.
  3. Lachman, L., Lieberman, H. A. and Kanig, J. L. The Theory and Practice of Industrial Pharmacy. CBS Publishers & Distributors.
  4. Allen, L. V., Popovich, N. G. and Ansel, H. C. and Drug Delivery Systems. Lippincott Williams & Wilkins.
  5. Cooper, S. J. and Gunn, C. CBS Publishers & Distributors. Course Code* Course Title* Course Type

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Official AKTU syllabus

This subject is on page 62, 63, 64 of the original AKTU PDF.

Official AKTU syllabus PDF ↗