General Pharmacology (Practical)

List of Experiments / Activities

1. General Pharmacology (Practical) Core Credit Hours Per Week (L-T-P) Max. Hours. L T P
2. 2-- --
3. 60Maximum Marks SE ESE
4. (Minimum 12 experiments must be performed)
5. 1To describe the contributions of renowned pharmacologists and their discoveries based on pharmacological experiments (Any 5 Noble Laureates whose research contributed to the development of Pharmacology).
6. 2To study various laboratory safety precautions, hazards, personal hygiene, commonly used tools, devices and instruments in experimental pharmacology.
7. 3To study common experimental animals including transgenic animals along with their applications in the pharmacological experiments in current drug discovery paradigm.
8. 4To study concept of 6Rs along with the maintenance and experimentation on laboratory animals as per the CCSEA guidelines.
9. 5To demonstrate collection/isolation of DNA and RNA using computer simulations and audiovisual aids.
10. 6To study important anaesthetics and euthanasia procedures for experimental animals.
11. 7To demonstrate different routes drug administration using computer simulation and understand the significance of each route along with the maximum administrable dose.
12. 8To study preparation of different types of physiological salt solutions (PSS), cell culture media and to understand the role of each ingredient used in PSS preparation.
13. 9To study the instrumentation used for isolated tissue experiments (students organ bath assembly) and recent development in recording of the responses of isolated tissues.
14. 10To record the dose response curve of any two agonists on suitable isolated tissue preparation using computer simulation experiment.
15. 11To study the potentiating effect of physostigmine on DRC of acetyl choline through interactive computer simulation.
16. 12To study antagonizing effect of d-tubocurarine on the DRCs of acetylcholine through interactive computer simulation.
17. 13To determine of PD2 of given agonists using isolated tissue preparation using computer simulation experiment.
18. 14To study and determine various pharmacokinetic parameters (Cmax, Tmax, Ke, t½, Vd, Clt, AUC, AUMC) from given hypothetical data.
19. 15-simulated experimentation (as per OECD 425 guideline) using software.
20. 16Software based quantification of micronucleus test and chromosomal aberration test
21. 17Software based prediction of teratogenicity.
22. 18Use of UV-Spectrophotometer for studying drug-protein interactions.