Pharmaceutical Dosage Forms II (Theory)

• The objectives of this course are to:
• Understand the principles of formulation and development of monophasic liquid dosage forms, including solvent selection and solubility enhancement techniques.
• Acquire knowledge of biphasic liquid dosage forms, including physicochemical principles, formulation strategies, manufacturing processes, and stability considerations.
• Develop competence in pressurised dosage forms such as aerosols, metered-dose inhalers, and dry powder inhalers, with emphasis on formulation design, device components, manufacturing, and quality evaluation.
• Understand the formulation, manufacturing, and evaluation of semisolid dosage forms, with emphasis on drug permeation through the skin and factors affecting topical drug delivery.
• Gain exposure to advanced drug delivery systems such as nanosuspensions, nanoemulsions, SMEDDS/SNEDDS, xerogels, and emulgels for improved therapeutic performance.

After completion of the course student will be able to:

1. CO1Explain the fundamental principles, classification, formulation requirements, and quality aspects of monophasic and biphasic liquid dosage forms.
2. CO2Formulate, manufacture, and evaluate monophasic and biphasic liquid preparations, including solutions, syrups, elixirs, suspensions, and emulsions, using appropriate excipients and processing techniques.
3. CO3DLVO theory, and emulsification theories to design stable liquid dosage forms and assess their stability and performance.
4. CO4Design and evaluate pressurized and inhalation dosage forms, including aerosols, metered dose inhalers, and dry powder inhalers, by selecting suitable formulation components, devices, and quality control parameters.
5. CO5Formulate, evaluate, and justify the use of semisolid and advanced drug delivery systems including ointments, creams, gels, suppositories, nanosuspensions, nano-emulsions, SMEDDS/SNEDDS, xerogels, and emulgels for enhanced drug delivery, stability, and patient compliance.

1. Aulton, M. E. Elsevier.
2. Gibson, M. Pharmaceutical Preformulation and Formulation. CRC Press.
3. Lachman, L., Lieberman, H. A. and Kanig, J. L. The Theory and Practice of Industrial Pharmacy. CBS Publishers & Distributors.
4. Robinson, J. R. and Lee, V. H. L. Controlled Drug Delivery: Fundamentals and Applications. CRC Press.
5. Troy, D. B. and Beringer, P. Remington: The Science and Practice of Pharmacy. Pharmaceutical Press.
6. Indian Pharmacopoeia. Indian Pharmacopoeia Commission. Course Title Course Type