Biomedicinal Chemistry (Practical)

• The objectives of this course are to:
• Comprehend the fundamental principles of drug synthesis and apply them to the preparation of selected drug molecules and intermediates.
• Develop practical skills in performing laboratory techniques for the synthesis of organic compounds, including the use of microwave irradiation.
• Understand and apply the principles of drug assay to quantitatively analyze the purity and concentration of given drug samples.
• Learn and utilize computational tools to predict physicochemical and ADME properties of drug molecules.
• Apply molecular docking techniques to predict drug-target interactions.

After completion of the course student will be able to:

1. CO1Successfully synthesize specified drug molecules and intermediates in the laboratory.
2. CO2Demonstrate competence in using microwave irradiation for efficient chemical synthesis.
3. CO3Accurately perform drug assays to determine the concentration and purity of drug samples.
4. CO4Analyze physicochemical and ADME properties of drug candidates using computational tools.
5. CO5Conduct and interpret molecular docking studies to understand drug-receptor binding.

1. Abraham, D. J. and Griffin, J. L. Wiley.
2. Finar, I. L. Organic Chemistry. Pearson Education.
3. Furniss, B. S., Hannaford, A. J., Smith, P. W. G. and Tatchell, A. R. Practical Organic Chemistry. Pearson Education.
4. Lednicer, D. The Organic Chemistry of Drug Synthesis. Wiley.
5. Patrick, G. L. An Introduction to Medicinal Chemistry. Oxford University Press.
6. Remington. The Science and Practice of Pharmacy. Pharmaceutical Press.
7. Williams, D. A., Lemke, T. L. and Roche, V. F. Chemistry. Lippincott Williams & Wilkins.
8. Wilson, C. O., Beale, J. M. and Block, J. H. Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins.
9. Indian Pharmacopoeia. Indian Pharmacopoeia Commission.
10. Brown, N. Artificial Intelligence in Drug Discovery. Cambridge: Royal Society of Chemistry. Course Title Course Type