BP607T AEC1

Green Chemistry (Theory)

L-T-P1-0-0 Session2026-27 TypeTheory
Appears in 1 semester

B.Pharm · Sem 6 (AEC – Elective 3)

Syllabus

5 units · 15 lecture hours
Unit1

Unit 1: Introduction to Green Chemistry in Pharmacy

3 hrs
  • Definition and scope of green chemistry in pharmaceutical sciences
  • Principles of Green Chemistry with pharmaceutical examples
Unit2

Unit 2

3 hrs

Environmental Aspects and Metrics in Green Pharmacy Comparison of traditional vs. green chemical approaches in drug synthesis Environmental impact of pharmaceutical manufacturing Overview of pharmaceutical pollutants and their life cycle Metrics: Atom economy, E-factor, Process Mass Intensity (PMI)

Unit3

Unit 3: Green Techniques in Pharmaceutical Synthesis I

3 hrs
  • Green Solvents and use of green solvents (e.g. water, supercritical fluids, ionic liquids) in drug synthesis
  • Solvent-free reactions in pharmaceutical synthesis
  • Green Catalysis and Reaction Enhancement in pharmaceutical green chemistry Overview of catalysis in pharmaceutical green chemistry, Photochemical Transformations, Phase Transfer Catalysis
Unit4

Unit 4

3 hrs
  • Green Techniques in Pharmaceutical Synthesis II
  • Microwave assisted reactions: Merit and demerits of its use
  • Mechanism, superheating effects of microwave
  • Effects of solvents in microwave assisted synthesis
  • Microwave technology in process optimization
  • Applications in various organic reactions and heterocycles synthesis
Unit5

Unit 5: Green Chemistry in Industrial and Regulatory Aspects

3 hrs
  • Green chemistry in pharmaceutical manufacturing processes
  • Ultrasound assisted reactions: Types of sonochemical reactions, synthetic applications
  • Continuous flow reactors: Working principle, advantages and synthetic applications
  • Waste minimization and pollution control in formulation industries
  • Role of green chemistry in Good Manufacturing Practices (GMP)
Course Objectives6 points
  • The objectives of this course are to:
  • Comprehend the foundational principles and overarching scope of green chemistry within pharmaceutical sciences.
  • Analyze and evaluate the environmental impact of traditional pharmaceutical manufacturing processes and the significance of green chemistry metrics.
  • Acquire knowledge of diverse green chemical techniques, including alternative solvents and various catalytic approaches, for sustainable drug synthesis.
  • Recognize the industrial application of green chemistry principles in pharmaceutical manufacturing processes, focusing on waste minimization and pollution control.
  • To articulate the principles of green chemistry.
Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Articulate the principles of green chemistry and provide relevant pharmaceutical examples for each.
  2. CO2Identify and propose suitable green solvents and catalysts,
  3. CO3Understand the advanced synthetic methods using Green synthesis using microwave, Ultrasonic for the production of active pharmaceutical ingredients (APIs).
  4. CO4Develop strategies for waste minimization and continuous flow reactor in pharmaceutical manufacturing in industries.
  5. CO5Articulate the principles of green chemistry and provide relevant pharmaceutical examples for each.
Recommended References (Preferably latest edition):5 books
  1. Anastas, P.T. and Warner, J.C., 2000. Green chemistry: theory and practice. Oxford university press.
  2. Lancaster, M. (2016). Green Chemistry: An Introductory Text (3rd ed.). Royal Society of Chemistry.
  3. Green Chemistry in the Pharmaceutical Industry, Edited by Peter J. Dunn, Andrew Wells, and Michael T. Williams, 2010.
  4. Green Chemistry and Sustainable Technology: Biological, Pharmaceutical, and Macromolecular Systems, Edited by Satish A. Dake, Ravindra S. Shinde, Suresh C. Ameta, A. K. Haghi, 2022.
  5. Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry, Edited by Stefan Koenig, 2013. Course Title Course Type

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Official AKTU syllabus

This subject is on page 234, 235, 236 of the original AKTU PDF.

Official AKTU syllabus PDF ↗