UNIQUE SERIES AKTU Syllabus
BP708T AEC7

Precision Medicine (Theory)

L-T-P1-0-0 Session2026-27 TypeTheory
Appears in 1 semester

B.Pharm · Sem 7 (AEC – Elective 6)

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Syllabus

5 units · 15 lecture hours
Unit1

Unit 1

3 hrs

Introduction to Precision Medicine and Its Relevance to Pharmacy Definition and scope of precision medicine -size-fits- Key components: genomics, epigenetics, environmental factors, lifestyle Role of pharmacists in precision medicine Interdisciplinary nature (clinicians, bioinformaticians, pharmacologists)

Unit2

Unit 2

3 hrs

Pharmacogenomics in Drug Response and Safety Basic human genetics relevant to pharmacy Genotype-phenotype relationships Genetic polymorphisms: CYP450 enzymes (CYP2D6, CYP2C9, etc.) FDA drug labelling and pharmacogenomic biomarkers Tools/databases: AlphaGenome, PharmGKB, CPIC, SNPedia

Unit3

Unit 3

4 hrs

Biomarkers, Targeted Therapy, and Companion Diagnostics Types of biomarkers: predictive, prognostic, diagnostic Role of biomarkers in targeted therapy Companion diagnostics: regulatory approval and clinical application Case study: Trastuzumab and HER2 testing in breast cancer Lab-on-chip and biosensor technologies Targeted nano-delivery in oncology Antibody-drug conjugates (ADCs) Smart delivery systems (stimuli-responsive biosensors)

Unit4

Unit 4

2 hrs

Technology, AI, and Big Data in Precision Medicine Role of AI, machine learning, and data analytics in precision medicine Electronic Health Records (EHRs), clinical decision support systems Integration of genomic data with patient profiles Examples of AI-driven drug discovery Data security and interoperability

Unit5

Unit 5

3 hrs

Regulatory, Ethical, and Clinical Implementation Regulatory guidelines (US FDA, EMA, CDSCO) for genomic-based therapies Clinical trial design for precision drugs Cost-effectiveness and access in low-resource settings Ethical issues: genetic testing, informed consent, data ownership Future of pharmacy practice in the precision medicine era

Course Objectives6 points
  • The objectives of this course are to:
  • Introduce the fundamental concepts, scope, and evolution of precision medicine and its relevance to modern pharmacy practice.
  • Provide an understanding of pharmacogenomics and the role of genetic variability in drug response, safety, and efficacy.
  • Explain the importance of biomarkers, targeted therapies, and companion diagnostics in personalized treatment strategies.
  • Introduce the emerging technologies such as artificial intelligence, big data analytics, and electronic health records in precision medicine.
  • Develop awareness of regulatory frameworks, ethical considerations, and clinical implementation challenges associated with genomic-based therapies.
Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Define precision medicine and explain its evolution from conventional therapy to personalized healthcare approaches, highlighting the role of pharmacists and interdisciplinary collaboration.
  2. CO2Describe basic human genetics and pharmacogenomic principles, and interpret genotype phenotype relationships affecting drug response and adverse drug reactions.
  3. CO3Analyze the role of genetic polymorphisms (e.g., CYP450 enzymes) and utilize pharmacogenomic resources and databases such as PharmGKB and CPIC in clinical decision-making.
  4. CO4Classify biomarkers and evaluate their role in targeted therapies and companion diagnostics, with reference to real-world clinical case studies as targeted nanocarriers, antibody drug conjugates, and smart delivery systems
  5. CO5Define precision medicine and explain its evolution from conventional therapy to personalized healthcare approaches, highlighting the role of pharmacists and interdisciplinary collaboration.
Recommended References (Preferably latest edition):3 books
  1. Genomic and Precision Medicine (3rd Edition) by Geoffrey S. Ginsburg & Huntington F. Willard
  2. Genomics and Personalized Medicine by Michael Snyder
  3. Deep Medicine by Eric Topol SEMESTER VIII Course Title Course Type

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Official AKTU syllabus

This subject is on page 272, 273, 274 of the original AKTU PDF.

Official AKTU syllabus PDF ↗